Identification and toxigenic potential of a cyanobacterial strain (Stigomena sp.)

Nowruzi, Bahareh; Khavari-Nejad, Ramazan Ali; Sivonen, Karina; Kazemi, Bahram; Najafi, Farzaneh; Nejadsattari, Taher

doi:10.22059/pbs.2013.32096

Identification and toxigenic potential of a cyanobacterial strain (Stigomena sp.)

Document Type : Research Paper

Authors

Bahareh Nowruzi ¹

Ramazan Ali Khavari-Nejad ²

Karina Sivonen ³

Bahram Kazemi ⁴

Farzaneh Najafi ¹

Taher Nejadsattari ⁵

¹ Faculty of Biological Sciences, Kharazmi University, Tehran, Iran

² 1Faculty of Biological Sciences, Kharazmi University, Tehran, Iran. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

³ Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland

⁴ Department of Biotechnology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

⁵ Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

10.22059/pbs.2013.32096

Abstract

Cyanobacteria are well known for their production of a multitude of highly toxic substances . The genus Stigomena is regarded as good candidates for producing biologically active secondary metabolites, which are highly toxic to humans and other animals. The carcass of a dog was found at the shore of Lake Ali-Abad, Iran. Biomass from the discovery site appeared to be of cyanobacterial nature. We identified the strain as freshwater bloom-forming representative of the Stigomena genus on the basis of its 16S rRNA sequence. It carried the mcyE gene, as well as a potential cryptic hassallidin gene cluster. These results suggest that microcystin-induced liver damage may have significantly ontributed to the death of the dog. This case is thus the first reported incident of potential microcystin intoxication in a dog in Iran.

Keywords

Cyanobacteria

Stigomena sp

Natural bioactive compound

Toxicity