PHD.University of Tehran
PHD.Pasteur Institute of Iran
PHD.Tehran University of Medical Sciences
PHD.Isfahan University of Medical Sciences
PHD.of Mathematics, Statistics and Computer Science, College of Science, University of Tehran, Tehran, Iran
IL-32 and TNF? are important cytokines in autoimmune and inflammatory diseases. IL-32 has not been previously studied with respect to MS. Here, we report IL-32 and TNF? transcript levels in peripheral blood mononuclear cells of MS patients and control individuals by real time PCR. A significant difference in IL-32 and TNF? mRNA levels of patients as compared to controls was not observed. However, patients with more recent attacks had highly significant increased levels of IL-32 mRNAs. As the sample size was small, this potentially relevant preliminary observation needs to be corroborated using a larger number of patients with well defined clinical features..? 2011 Progress in Biological Sciences. Vol. 1, No. 2, 44-49.