Preliminary data suggest possible association between IL-32 expression level and time of MS attack


1 PHD.University of Tehran

2 PHD.Pasteur Institute of Iran

3 PHD.Tehran University of Medical Sciences

4 PHD.Isfahan University of Medical Sciences

5 PHD.of Mathematics, Statistics and Computer Science, College of Science, University of Tehran, Tehran, Iran


IL-32 and TNF? are important cytokines in autoimmune and inflammatory diseases. IL-32 has not been previously studied with respect to MS. Here, we report IL-32 and TNF? transcript levels in peripheral blood mononuclear cells of MS patients and control individuals by real time PCR. A significant difference in IL-32 and TNF? mRNA levels of patients as compared to controls was not observed. However, patients with more recent attacks had highly significant increased levels of IL-32 mRNAs. As the sample size was small, this potentially relevant preliminary observation needs to be corroborated using a larger number of patients with well defined clinical features..? 2011 Progress in Biological Sciences. Vol. 1, No. 2, 44-49.