Preliminary data suggest possible association between IL-32 expression level and time of MS attack

Roghani, Mehrzad; Mahboudi, Fereidoun; Sahraian, Mohammad Ali; Etemadifar, Masoud; Elahi, Elahe

doi:10.22059/pbs.2011.24289

Preliminary data suggest possible association between IL-32 expression level and time of MS attack

Authors

Mehrzad Roghani ¹

Fereidoun Mahboudi ²

Mohammad Ali Sahraian ³

Masoud Etemadifar ⁴

Elahe Elahi ⁵

¹ PHD.University of Tehran

² PHD.Pasteur Institute of Iran

³ PHD.Tehran University of Medical Sciences

⁴ PHD.Isfahan University of Medical Sciences

⁵ PHD.of Mathematics, Statistics and Computer Science, College of Science, University of Tehran, Tehran, Iran

10.22059/pbs.2011.24289

Abstract

IL-32 and TNF? are important cytokines in autoimmune and inflammatory diseases. IL-32 has not been previously studied with respect to MS. Here, we report IL-32 and TNF? transcript levels in peripheral blood mononuclear cells of MS patients and control individuals by real time PCR. A significant difference in IL-32 and TNF? mRNA levels of patients as compared to controls was not observed. However, patients with more recent attacks had highly significant increased levels of IL-32 mRNAs. As the sample size was small, this potentially relevant preliminary observation needs to be corroborated using a larger number of patients with well defined clinical features..? 2011 Progress in Biological Sciences. Vol. 1, No. 2, 44-49.

Keywords

mRNA

patients

preliminary

TNFα