%0 Journal Article %T Preliminary data suggest possible association between IL-32 expression level and time of MS attack %J Progress in Biological Sciences %I University of Tehran Press %Z 1016-1058 %A Roghani, Mehrzad %A Mahboudi, Fereidoun %A Sahraian, Mohammad Ali %A Etemadifar, Masoud %A Elahi, Elahe %D 2011 %\ 10/01/2011 %V 1 %N 2 %P 44-49 %! Preliminary data suggest possible association between IL-32 expression level and time of MS attack %K mRNA %K patients %K preliminary %K TNFα %R 10.22059/pbs.2011.24289 %X IL-32 and TNF? are important cytokines in autoimmune and inflammatory diseases. IL-32 has not been previously studied with respect to MS. Here, we report IL-32 and TNF? transcript levels in peripheral blood mononuclear cells of MS patients and control individuals by real time PCR. A significant difference in IL-32 and TNF? mRNA levels of patients as compared to controls was not observed. However, patients with more recent attacks had highly significant increased levels of IL-32 mRNAs. As the sample size was small, this potentially relevant preliminary observation needs to be corroborated using a larger number of patients with well defined clinical features..? 2011 Progress in Biological Sciences. Vol. 1, No. 2, 44-49. %U https://pbiosci.ut.ac.ir/article_24289_688b1a8ec37c08d510821b230c288ff0.pdf