Dendrosomal nano-curcumin; The novel formulation to improve the anticancer properties of curcumin

Document Type: Research Paper

Authors

1 Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Department of Biotechnology, Faculty of advanced Medical Technology, Golestan University of Medical sciences, Gorgan, Iran

3 Department of Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran

4 Department of Resin and Additives, Institute for Color Science and Technology

5 Department of Genetics, Faculty of biological sciences, Tarbiat Modares Univesity of Tehran, Tehran, Iran

Abstract

Curcumin is a hydrophobic polyphenol extracted from the plant curcuma longa with established
anticancer properties. However, curcumin benefits have been impaired by its very low water
solubility, low absorption, rapid metabolism and clearance from the body. Recently,
nanotechnology promises to be helpful in development of drugs delivery systems by recent
advances in macromolecular design of nanocarriers. In this review, we present the novel
generation of nano-vehicles termed dendrosomes which are readily synthesized from
esterification of oleic acid and polyethylene glycol residues. Dendrosomes efficiently
encapsulate curcumin in a spherical micellar or polymersome structures which leads to increase
aqueous solubility of this hydrophobic agent and higher bioavailability of curcumin. Anticancer
potency of this nanoformulation was confirmed in different mouse and human cancer
cells including fibrosarcoma, colon, glioblastoma, bladder, gastric, breast and hepatocellular
carcinoma in vitro and vivo. It has also demonstrated that this nano preparation has no
cytotoxicity effects on normal cells. Finally, these results introduce dendrosomal curcumin as
potent anti-tumor agent although further clinical examinations are needed.

Keywords

Main Subjects


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