University of Tehran Press Progress in Biological Sciences 1016-1058 5 2 2015 07 01 Dendrosomal nano-curcumin; The novel formulation to improve the anticancer properties of curcumin 143 158 55525 10.22059/pbs.2015.55525 EN Maryam Tahmasebi Birgani Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Vahid Erfani-Moghadam Department of Biotechnology, Faculty of advanced Medical Technology, Golestan University of Medical sciences, Gorgan, Iran Esmail Babaei Department of Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran Farhood Najafi Department of Resin and Additives, Institute for Color Science and Technology Mina Zamani Department of Genetics, Faculty of biological sciences, Tarbiat Modares Univesity of Tehran, Tehran, Iran Molood Shariati Department of Genetics, Faculty of biological sciences, Tarbiat Modares Univesity of Tehran, Tehran, Iran Shima Nazem Department of Genetics, Faculty of biological sciences, Tarbiat Modares Univesity of Tehran, Tehran, Iran Baharak Farhangi Department of Genetics, Faculty of biological sciences, Tarbiat Modares Univesity of Tehran, Tehran, Iran Paria Motahari Department of Genetics, Faculty of biological sciences, Tarbiat Modares Univesity of Tehran, Tehran, Iran Majid Sadeghizadeh Department of Genetics, Faculty of biological sciences, Tarbiat Modares Univesity of Tehran, Tehran, Iran Journal Article 2015 03 01 Curcumin is a hydrophobic polyphenol extracted from the plant curcuma longa with established<br />anticancer properties. However, curcumin benefits have been impaired by its very low water<br />solubility, low absorption, rapid metabolism and clearance from the body. Recently,<br />nanotechnology promises to be helpful in development of drugs delivery systems by recent<br />advances in macromolecular design of nanocarriers. In this review, we present the novel<br />generation of nano-vehicles termed dendrosomes which are readily synthesized from<br />esterification of oleic acid and polyethylene glycol residues. Dendrosomes efficiently<br />encapsulate curcumin in a spherical micellar or polymersome structures which leads to increase<br />aqueous solubility of this hydrophobic agent and higher bioavailability of curcumin. Anticancer<br />potency of this nanoformulation was confirmed in different mouse and human cancer<br />cells including fibrosarcoma, colon, glioblastoma, bladder, gastric, breast and hepatocellular<br />carcinoma in vitro and vivo. It has also demonstrated that this nano preparation has no<br />cytotoxicity effects on normal cells. Finally, these results introduce dendrosomal curcumin as<br />potent anti-tumor agent although further clinical examinations are needed. https://pbiosci.ut.ac.ir/article_55525_6ee862d2c180dd281137714f73b97432.pdf