TY - JOUR ID - 59009 TI - Isolation of biologically active Actinomycetes from untouched soils: a case study from Karaj district, Iran JO - Progress in Biological Sciences JA - PBS LA - en SN - 1016-1058 AU - salehghamari, ensieh AU - Najafi, Maryam AD - Microbiology Lab. Department of Cell and Molecular Sciences Faculty of Biological Sciences Kharazmi University Karaj-Iran Y1 - 2016 PY - 2016 VL - 6 IS - 1 SP - 65 EP - 74 KW - Alborz Province KW - Antimicrobial activity KW - Methicillin resistant Staphylococcus aureus DO - 10.22059/pbs.2016.59009 N2 - Actinomycetes are a source of a broad variety of secondary metabolites with diverse biological activities, such as antifungi, antibiotics and antitumorals; many of which have been developed for clinical use. In this study, 34 actinomycetes from untouched soils were isolated from Alborz Province-Iran. Evaluation ofantifungal and anti bacterial activities of these isolates, demonstrated the capability of the isolates to inhibit the growth of fungi and bacteria using agar well diffusion method. Moreover, the ethyl acetate and ethanol extracts of an isolate were also tested against Staphylococcus aureus (MRSA) and their inhibited zones were measured. 53% of isolates were active against at least one of the seven tested pathogens and 32% of actinomycetes were active against tested pathogenic fungi. Some of the actinomycetal isolates had shown strong antifungal and antibacterial activity which promises a good source of novel antimicrobial agents. As a case, isolate act-3 was selected for its high antimicrobial activity against MRSA. These results suggested that actinomycetes from Alborz Province have a good potential for the production of biologically active compounds. UR - https://pbiosci.ut.ac.ir/article_59009.html L1 - https://pbiosci.ut.ac.ir/article_59009_d8191095295a783aa0800449ca614bcb.pdf ER -